An exercise-inducible metabolite that suppresses feeding and obesity – Nature

  • Eriksson, K. F. & Lindgärde, F. Prevention of type 2 (non-insulin-dependent) diabetes mellitus by diet and physical exercise. Diabetologia 34, 891–898 (1991).

    CAS 
    Article 

    Google Scholar 

  • Rejeski, W. J. et al. Lifestyle change and mobility in obese adults with type 2 diabetes. N. Engl. J. Med. 366, 1209–1217 (2012).

    CAS 
    Article 

    Google Scholar 

  • Stampfer, M. J., Hu, F. B., Manson, J. E., Rimm, E. B. & Willett, W. C. Primary prevention of coronary heart disease in women through diet and lifestyle. N. Engl. J. Med. 343, 16–22 (2000).

    CAS 
    Article 

    Google Scholar 

  • Helmrich, S. P., Ragland, D. R., Leung, R. W. & Paffenbarger, R. S. Physical activity and reduced occurrence of non-insulin-dependent diabetes mellitus. N. Engl. J. Med. 325, 147–152 (1991).

    CAS 
    Article 

    Google Scholar 

  • Rawshani, A. et al. Risk factors, mortality, and cardiovascular outcomes in patients with type 2 diabetes. N. Engl. J. Med. 379, 633–644 (2018).

    Article 

    Google Scholar 

  • Sanford, J. A. et al. Molecular Transducers of Physical Activity Consortium (MoTrPAC): mapping the dynamic responses to exercise. Cell 181, 1464–1474 (2020).

    CAS 
    Article 

    Google Scholar 

  • Contrepois, K. et al. Molecular choreography of acute exercise. Cell 181, 1112–1130.e16 (2020).

    CAS 
    Article 

    Google Scholar 

  • Morville, T., Sahl, R. E., Moritz, T., Helge, J. W. & Clemmensen, C. Plasma metabolome profiling of resistance exercise and endurance exercise in humans. Cell Rep. 33, 108554 (2020).

    CAS 
    Article 

    Google Scholar 

  • Lewis, G. D. et al. Metabolic signatures of exercise in human plasma. Sci. Transl. Med. 2, 33ra37 (2010).

    Article 

    Google Scholar 

  • Roberts, L. D. et al. β-Aminoisobutyric acid induces browning of white fat and hepatic β-oxidation and is inversely correlated with cardiometabolic risk factors. Cell Metab. 19, 96–108 (2014).

    CAS 
    Article 

    Google Scholar 

  • Stanford, K. I. et al. 12,13-diHOME: an exercise-induced lipokine that increases skeletal muscle fatty acid uptake. Cell Metab. 27, 1111–1120.e3 (2018).

    CAS 
    Article 

    Google Scholar 

  • Reddy, A. et al. pH-gated succinate secretion regulates muscle remodeling in response to exercise. Cell 183, 62–75.e17 (2020).

    CAS 
    Article 

    Google Scholar 

  • Yuan, Y. et al. Exercise-induced α-ketoglutaric acid stimulates muscle hypertrophy and fat loss through OXGR1-dependent adrenal activation. EMBO J. 39, e103304 (2020).

    CAS 
    Article 

    Google Scholar 

  • Klein, A. B. et al. Pharmacological but not physiological GDF15 suppresses feeding and the motivation to exercise. Nat. Commun. 12, 1041 (2021).

    ADS 
    CAS 
    Article 

    Google Scholar 

  • Green, H. J. & Fraser, I. G. Differential effects of exercise intensity on serum uric acid concentration. Med. Sci. Sports Exerc. 20, 55–59 (1988).

    CAS 
    Article 

    Google Scholar 

  • Schranner, D., Kastenmüller, G., Schönfelder, M., Römisch-Margl, W. & Wackerhage, H. Metabolite concentration changes in humans after a bout of exercise: a systematic review of exercise metabolomics studies. Sport. Med. Open 6, 11 (2020).

    Article 

    Google Scholar 

  • Gaffney, B. & Cunningham, E. P. Estimation of genetic trend in racing performance of thoroughbred horses. Nature 332, 722–724 (1988).

    ADS 
    CAS 
    Article 

    Google Scholar 

  • Hagenfeldt, L. & Naglo, A. S. New conjugated urinary metabolites in intermediate type maple syrup urine disease. Clin. Chim. Acta 169, 77–83 (1987).

    CAS 
    Article 

    Google Scholar 

  • Bottesini, C., Tedeschi, T., Dossena, A. & Sforza, S. Enzymatic production and degradation of cheese-derived non-proteolytic aminoacyl derivatives. Amino Acids 46, 441–447 (2014).

    CAS 
    Article 

    Google Scholar 

  • Sgarbi, E. et al. Microbial origin of non proteolytic aminoacyl derivatives in long ripened cheeses. Food Microbiol. 35, 116–120 (2013).

    CAS 
    Article 

    Google Scholar 

  • Jansen, R. S. et al. N-lactoyl-amino acids are ubiquitous metabolites that originate from CNDP2-mediated reverse proteolysis of lactate and amino acids. Proc. Natl Acad. Sci. USA 112, 6601–6606 (2015).

    ADS 
    CAS 
    Article 

    Google Scholar 

  • Sharma, R. et al. Circulating markers of NADH-reductive stress correlate with mitochondrial disease severity. J. Clin. Invest. 131, e136055 (2021).

    CAS 
    Article 

    Google Scholar 

  • The Tabula Muris Consortium. Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris. Nature 562, 367–372 (2018).

    ADS 
    CAS 
    Article 

    Google Scholar 

  • Locke, A. E. et al. Genetic studies of body mass index yield new insights for obesity biology. Nature 518, 197–206 (2015).

    CAS 
    Article 

    Google Scholar 

  • Ringholm, S. et al. PGC-1α is required for exercise- and exercise training-induced UCP1 up-regulation in mouse white adipose tissue. PLoS ONE 8, e64123 (2013).

    ADS 
    Article 

    Google Scholar 

  • Kim, Y. J., Kim, H. J., Lee, W. J. & Seong, J. K. A comparison of the metabolic effects of treadmill and wheel running exercise in mouse model. Lab. Anim. Res. 36, 1–8 (2020).

    Article 

    Google Scholar 

  • De Wolf, C. J. F. et al. cGMP transport by vesicles from human and mouse erythrocytes. FEBS J. 274, 439–450 (2007).

    Article 

    Google Scholar 

  • Smith, C. A. et al. XCMS: processing mass spectrometry data for metabolite profiling using nonlinear peak alignment, matching, and identification. Anal. Chem. 78, 779–787 (2006).

    CAS 
    Article 

    Google Scholar 

  • Agudelo, L. Z. et al. Skeletal muscle PGC-1α1 modulates kynurenine metabolism and mediates resilience to stress-induced depression. Cell 159, 33–45 (2014).

    CAS 
    Article 

    Google Scholar 

  • Coxon, J. P. et al. GABA concentration in sensorimotor cortex following high-intensity exercise and relationship to lactate levels. J. Physiol. 596, 691–702 (2018).

    CAS 
    Article 

    Google Scholar 

  • Human Energy Requirements: Report of a Joint FAO/WHO/UNU Expert Consultation (FAO, WHO, UNU, 2005).

  • Sanjana, N. E., Shalem, O. & Zhang, F. Improved vectors and genome-wide libraries for CRISPR screening. Nat. Methods 11, 783–784 (2014).

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